Firing behaviour in stochastic nerve membrane models with different pore densities
作者:
ERIK SKAUGEN,
期刊:
Acta Physiologica Scandinavica
(WILEY Available online 1980)
卷期:
Volume 108,
issue 1
页码: 49-60
ISSN:0001-6772
年代: 1980
DOI:10.1111/j.1748-1716.1980.tb06499.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
A stochastic nerve membrane model with a two‐state pore system was investigated by computer simulation in the uniform (space‐clamped) case. The model was based upon the Hodgkin‐Huxley equations for the giant axon in squid, but where both the maximal membrane conductances and the rate constants were changed systematically. This was done in order to simulate nerve membranes of small axons, where both of these parameters are smaller than in squid. It was found that the effects upon the firing behaviour due to a finite number of pores were not greatly affected by changes in these parameters. When the specific injected current was calculated relative to the maximal membrane conductances, the threshold for firing was increased somewhat, and the frequency‐current relationship became slightly more linear when the maximal conductances (or pore density) were decreased, or the rate constants increased. In the discussion it is shown how the results obtained could be applied qualitatively to the firing behaviour of nerve cells, and that firing in small nerve cells should be significantly influenced by the stochastic effects of a finite number of pores. Gating currents were also discussed, and their effects were found to be insignificant in small nerv
点击下载:
PDF
(836KB)
返 回