A POORLY DIFFERENTIATED LYMPHOMA OF DONOR ORIGIN IN A RENAL ALLOGRAFT RECIPIENT
作者:
BRIAN HJELLE,
MARTHA EVANS-HOLM,
T. Benedict Yen,
MARVIN GAROVOY,
MARGOT GUIS,
JEFFREY EDMAN,
期刊:
Transplantation
(OVID Available online 1989)
卷期:
Volume 47,
issue 6
页码: 945-948
ISSN:0041-1337
年代: 1989
出版商: OVID
数据来源: OVID
摘要:
Malignant lymphoma is a frequent complication of organ transplantation. It has been suggested that such tumors arise as a result of uncontrolled proliferation of Epstein-Barr virus-infected B lymphocytes in an immunosuppressed host. Although a few cases of posttransplant lymphomas in bone marrow transplantation have been shown to be of donor cell origin, no recipients of solid-organ transplants are known to have developed lymphomas arising from donor cells. In this report, a case of diffuse high-grade lymphoma that apparently arose in the allograft of a renal transplant recipient is described. DNA fingerprinting demonstrated the tumor to be of donor origin; Epstein-Barr sequences were absent. A therapeutic trial consisting of withdrawal of immunosuppressive agents and administration of acyclovir was unsuccessful. These data support the notion that donor cells can undergo malignant transformation in solid-organ transplant recipients, and such tumors need not carry EBV genetic material.
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