Linomide inhibits programmed cell death of peripheral T cellsin vivo
作者:
José Angel Gonzal,
Ana Gonźlez‐Garciá,
Terje Kalland,
Gunnar Hedlund,
Carlos Martínez‐A,
Guido Kroemer,
期刊:
European Journal of Immunology
(WILEY Available online 1994)
卷期:
Volume 24,
issue 1
页码: 48-52
ISSN:0014-2980
年代: 1994
DOI:10.1002/eji.1830240108
出版商: WILEY‐VCH Verlag GmbH
关键词: Apoptosis;Glucocorticoid;Linomide;Programmed cell death;Superantigen
数据来源: WILEY
摘要:
AbstractProgrammed cell death (PCD) is involved in the physiological regulation of lymphocyte turnover, as well in the antigen‐driven selection of T and B cells. Here it is shown that the immunomodulator linomide (quinoline‐3‐carboxamide) inhibits the apoptotic decay of peripheral T lymphocytes in response to three different stimuli. First, linomide reduces the superantigen‐mediated apoptosis and deletion of specific T lymphocytes of both the CD4+and the CD8+subsets without affecting other superantigen‐triggered phenomena such as T cell expansion and anergy. Second, linomide abolishes the T lymphopenia and inhibits PCD of splenic CD4+and CD8+T cells induced by exogenous glucocorticoids. This effect is restricted to peripheral T lymphocytes and does not concern thymocytes. Finally, linomide abolishes the development of lymphopenia that follows infection with vaccinia virus, while reducing PCD of CD4+and CD8+peripheral T cells. The anti‐apoptotic effect of linomide could account for its immunostimulatory properties and might be relevant to the treatment of immunodeficiencies associated with an increased apoptotic decay of T
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