Purification and Sequence of a Novel Ovine Adrenal Medullary Peptide and Its Precursor
作者:
Radmila Micanovic,
Purnima Ray,
William Kruggel,
Randolph V. Lewis,
期刊:
Neuroendocrinology
(Karger Available online 1985)
卷期:
Volume 41,
issue 3
页码: 197-200
ISSN:0028-3835
年代: 1985
DOI:10.1159/000124178
出版商: S. Karger AG
关键词: Adrenal medulla;Peptide;bioactive;Precursor
数据来源: Karger
摘要:
A 24 amino acid polypeptide that does not originate from (pre)proenkephalin has been isolated from ovine adrenal chromaffin granules. Its sequence is: Arg-Leu-Pro-Gly-Glu-Leu-Arg-Asn-Tyr-Leu-Asp-Tyr-Gly-Glu-Glu-Val-Gly-Glu-Glu-Ala-Ala-Arg-Gly-Val. This peptide is generated from a precursor molecule that has also been purified and partially sequenced. The proteolytic cleavage occurs at a triple Arg site. A search of the available protein sequence data banks shows very little homology to any known protein.
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