Open Trials with Valproate in Epilepsy
作者:
Olivier Dulac,
Michel Arthuis,
期刊:
Epilepsia
(WILEY Available online 1984)
卷期:
Volume 25,
issue 1
页码: 23-31
ISSN:0013-9580
年代: 1984
DOI:10.1111/j.1528-1157.1984.tb05633.x
出版商: Blackwell Publishing Ltd
关键词: Valproate;Valproic acid;Clinical studies review
数据来源: WILEY
摘要:
Valproic acid (VPA) was first synthesized in the United States (Burton, 1882) and was used worldwide for 80 years as an organic solvent. Its unexpected antiepileptic activity was discovered 20 years ago in Grenoble, France (Meunier et al., 1963; Carraz et al., 1964). The aim of this work is to report the progressive evolution of ideas and the clinical approach to the treatment of epilepsy with sodium valproate (Na VPA) and VPA, according to published open trials and to our own unpublished data.
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