Spinal Sufentanil Effects on Spinal Pain‐transmission Neurons in Cats
作者:
M.,
Aoki M.,
Senami L.,
Kitahata J.,
期刊:
Anesthesiology
(OVID Available online 1986)
卷期:
Volume 64,
issue 2
页码: 225-229
ISSN:0003-3022
年代: 1986
出版商: OVID
关键词: Analgesics: sufentanil;Anesthetic techniques: spinal narcotics;Spinal cord: neurons, WDR
数据来源: OVID
摘要:
The ability of sufentanil to suppress noxiously evoked activity of wide dynamic range (WDR) neurons was studied in decerebrate, spinal-cord-transected cats. Sufentanil, 2.5 ug (n = 7) or 5.0 ug (n = 7), when administered spinally, produced a significant, dose-dependent suppression of noxiously evoked (51 °C radiant heat stimulus) activity of WDR neurons in the dorsal horn of the spinal cord. Spontaneous recovery from sufentanil suppression was not seen for up to 2 h. Reversal following intravenous naloxone, 0.12 mg, although present, was not as complete as that seen following other spinal opiates. Intravenous sufentanil, 5.0 ug/kg (n=4), produced significant but short-lasting depression of noxiously evoked WDR neuron activity. A comparison of the results of this study with data from a previous fentanyl study suggests that sufentanil may be more appropriate than fentanyl for spinal or epidural administration because of a possible longer duration of action. However, the lesser degree of naloxone reversal seen in this study may suggest that, clinically, reversal of sufentanil effects may be more difficult.
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