Characterization of a 28-kD Polymorphic Polypeptide Detected by Two-Dimensional Electrophoresis of Human Platelets
作者:
S. Iwamoto,
E. Kajii,
T. Omi,
S. Tsuchida,
S. Ikemoto,
期刊:
Human Heredity
(Karger Available online 1992)
卷期:
Volume 42,
issue 5
页码: 276-279
ISSN:0001-5652
年代: 1992
DOI:10.1159/000154082
出版商: S. Karger AG
关键词: Polymorphic polypeptide;Human platelet;Two-dimensional electrophoresis
数据来源: Karger
摘要:
A genetic polymorphism of a human platelet polypeptide with a molecular weight of 28 kD detected by two-dimensional electrophoresis was investigated in family and population studies, and cell distribution. The 28-kD polypeptide showed autosomal codominant inheritance of two alleles. The gene frequencies of the two alleles were 0.925 and 0.075, respectively. The 28-kD polypeptide was observed in lymphocytes, neutrophils, eosinophils and monocytes, in addition to platelets. This polypeptide showed good reproducibility in electrophoresis, and appears to be useful as a genetic marker of the human genome in gene mapping and pedigree analysis.
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