Evaluation of Methods for the Quantification of Experimental Myocardial Infarction
作者:
ARTHUR ROBERTS,
PAUL CIPRIANO,
DANIEL ALONSO,
JEROME JACOBSTEIN,
JOHN COMBES,
WILLIAM GAY,
期刊:
Circulation
(OVID Available online 1978)
卷期:
Volume 57,
issue 1
页码: 35-41
ISSN:0009-7322
年代: 1978
出版商: OVID
数据来源: OVID
摘要:
Several invasive and noninvasive techniques used in determining the size of experimental myocardial infarction were evaluated after acute ligation of the left anterior descending (LAD) coronary artery in ten dogs. Systemic blood pressure, left ventricular end-diastolic pressure (LVEDP), and heart rate did not change significantly for up to 24 hours after coronary occlusion. Left ventricular wall motion abnormalities were detected by left ventriculography in the distribution of the LAD but these changes did not correlate well with the infarct weight determined at autopsy.On the other hand, the number of epicardial sites with ST-segment elevation of ?2mm (mean 15.1 sites ± 0.6 SEM) and the infarct area as measured by “mTc-glucoheptonate (TcGH) myocardial imaging (15.7 sq cm ± 0.6) did correlate strongly with the infarct weight (16.8 g i 0.7) determined by the nitroblue tetrazolium (NBT) technique (r 0.91).TcGH myocardial scintigraphy and epicardial ST-segment mapping allowed early and accurate quantification of experimental myocardial infarcts ranging from < 1 g to 28 g.
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