Antigenic Specificity of Antibodies from Patients with Linear Basement Membrane Deposition of IgA
作者:
J.J. Zone,
Pazderka Smith,
D. Powell,
T.B. Taylor,
J.B. Smith,
L.J. Meyer,
期刊:
Dermatology
(Karger Available online 1994)
卷期:
Volume 189,
issue 1
页码: 64-66
ISSN:1018-8665
年代: 1994
DOI:10.1159/000246933
出版商: S. Karger AG
关键词: IgA;linear;Cicatricial pemphigoid;Autoantigen;Chronic bullous disease of childhood
数据来源: Karger
摘要:
We reviewed the immunoreactivity of sera binding to the epidermal side of basement membrane split skin from 13 adults and 8 children with IgA alone, 9 adults with IgA and IgG and 7 adults with IgA and ocular pemphigoid. Immunoblots were done against previously described 45-, 97-, 180- and 230-kD antigens, and reactivity was confirmed by elution of antibody from nitrocellulose and binding to the basement membrane. Ten of 13 adults and 7 of 8 children reacted with the 97-kD antigen. Sera with both IgA and IgG reacted in varying patterns and on occasion with more than 1 antigen. All 7 patients with ocular cicatricial pemphigoid reacted uniquely with a 45-kD antigen.
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