DNA index as a significant indicator of lymph node metastasis and local recurrence of rectal cancer
作者:
Osamu Kimura,
Toshihisa Kijima,
Seiji Moriwaki,
Kazuyoshi Hoshino,
Masao Yonekawa,
Akira Sugezawa,
Nobuaki Kaibara,
期刊:
Diseases of the Colon & Rectum
(OVID Available online 1992)
卷期:
Volume 35,
issue 12
页码: 1130-1134
ISSN:0012-3706
年代: 1992
出版商: OVID
关键词: DNA content;DNA index;Lymph node metastasis;Local recurrence;Rectal cancer
数据来源: OVID
摘要:
&NA;To confirm the prognostic significance of the DNA index (DI) in cases of rectal cancer, the nuclear DNA content of tumor cells was examined in 184 cases of rectal cancer treated with curative surgery, and the incidence of lymph node metastasis and recurrence of the cancer was analyzed. The incidence of lymph node metastasis was 43.9 percent in cases with aneuploidy (DI above 1.5), being statistically different from the 18.0 percent incidence in cases with diploidy(P<0.001). Although the extent of lymph node metastasis was limited to adjacent lymph nodes in cases with diploidy, distant lymph node metastases were frequent in cases with aneuploidy, especially in those with a DI above 1.5. Furthermore, the incidence of recurrence of cancer, and especially of local recurrence, was significantly higher(P<0.001) in cases with aneuploidy (DI above 1.5) than in cases with diploidy and aneuploidy (DI below 1.4). These findings indicate the significant value of the DNA index for the prediction of lymph node metastasis and local recurrence in patients with rectal cancer.
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