Alprazolam Pharmacokinetics in Alcoholic Liver Disease
作者:
RANDY P. JUHL,
DAVID H. THIEL,
LEWIS W. DITTERT,
RANDALL B. SMITH,
期刊:
The Journal of Clinical Pharmacology
(WILEY Available online 1984)
卷期:
Volume 24,
issue 2‐3
页码: 113-119
ISSN:0091-2700
年代: 1984
DOI:10.1002/j.1552-4604.1984.tb02773.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
Abstract:Alprazolam, a triazolobenzodiazepine, was administered to 17 patients with alcoholic liver disease. The pharmacokinetic parameters derived from plasma alprazolam concentrations were compared with data obtained from 17 normal subjects who were matched for age and sex. The rate of absorption of alprazolam was slower in patients with alcoholic liver disease. The time of maximum serum concentration was 3.3 hours, compared with 1.5 hour in normals (P<0.02). The maximum concentrations, however, did not differ (18.4 vs. 17.2 μg/ml). The elimination half‐life of drug was longer in the patients (19.7 hours) than in the normal subjects (11.4 hours), while the clearance of the drug was slower in the patients with alcoholic liver disease (0.6 vs. 1.2 ml/min/kg). The volumes of distribution (area) did not differ between the two groups (1.1 vs. 1.2 liter/kg). The changes in elimination half‐life and clearance indicate that the metabolism of the drug is slowed in patients with alcoholic liver dis
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