Endothelial Dysfunction in Cardiovascular DiseasesThe Role of Oxidant Stress
作者:
Hua Cai,
David Harrison,
期刊:
Circulation Research: Journal of the American Heart Association
(OVID Available online 2000)
卷期:
Volume 87,
issue 10
页码: 840-844
ISSN:0009-7330
年代: 2000
出版商: OVID
关键词: superoxide;nitric oxide;endothelium;NADH/NADPH oxidase;xanthine oxidase
数据来源: OVID
摘要:
Accumulating evidence suggests that oxidant stress alters many functions of the endothelium, including modulation of vasomotor tone. Inactivation of nitric oxide (NO·) by superoxide and other reactive oxygen species (ROS) seems to occur in conditions such as hypertension, hypercholesterolemia, diabetes, and cigarette smoking. Loss of NO·associated with these traditional risk factors may in part explain why they predispose to atherosclerosis. Among many enzymatic systems that are capable of producing ROS, xanthine oxidase, NADH/NADPH oxidase, and uncoupled endothelial nitric oxide synthase have been extensively studied in vascular cells. As the role of these various enzyme sources of ROS become clear, it will perhaps be possible to use more specific therapies to prevent their production and ultimately correct endothelial dysfunction.
点击下载:
PDF
(47KB)
返 回