首页   按字顺浏览 期刊浏览 卷期浏览 Enhanced Incorporation of 1-β-D-Arabinofuranosylcytosine by Pretreatment with Etoposide
Enhanced Incorporation of 1-β-D-Arabinofuranosylcytosine by Pretreatment with Etoposide

 

作者: OoiKazuya,   OhkuboToshiki,   KuwabaraHiroshi,   HigashigawaMasamune,   KawasakiHajime,   KakitohHideshi,   KagawaYoshiyuki,   InagakiShoji,   SumidaKatsumi,   SakuraiMinoru,  

 

期刊: Cancer Investigation  （Taylor Available online 1993）
卷期: Volume 11, issue 4  

页码: 388-392

 

ISSN:0735-7907

 

年代: 1993

 

DOI:10.3109/07357909309018870

 

出版商: Taylor&Francis

 

数据来源: Taylor

 

摘要:

We examined the effects of timing of administration of etoposide on cytosine arab-inoside (ara-C) incorporation into DNA in L1210 ascites tumor. At 1 hr after injection of ara-C, 3-hr and 6-hr pretreatments with 15 mg/kg of etoposide increased ara-C incorporation to more than 200% as compared to that of ara-C given alone. Simultaneous administration of etoposide, however, decreased ara-C incorporation to 33% of that of ara-C alone. These results might explain the previously reported sequence dependency of the antitumor effect of etoposide and ara-C.

 

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