Multiple classes of the oligodendrocyte lineage are highly vulnerable to excitotoxicity
作者:
John McDonald,
Joel Levine,
Yun Qu,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 12
页码: 2757-2762
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Cell culture;Excitatory amino acid receptors;Excitotoxicity;Gal-C (galactocerebroside);Glutamate;Kainate;Myelination;MBP (myelin basic protein);NG2;O2-A progenitors;Oligodendrocytes
数据来源: OVID
摘要:
WE have recently shown that galactocerebroside (Gal-C)-expressing oligodendrocytes are highly vulnerable to (AMPA)/kainate receptor-mediated death. Here we examined the vulnerability of cells at different developmental stages of the oligodendrocyte lineage to AMPA/kainate receptor-mediated excitotoxicity. Oligodendrocyte precursor cells, pre-oligodendrocytes and mature oligodendrocytes were killed by 24 h exposures to low concentrations of kainate (30–100 μM). Death was attenuated by the AMPA/kainate receptor antagonist 6-nitro-7-sulfamoylbenzo(f)quinoxaline-2,3-dione (NBQX). The high vulnerability of oligodendrocytes and their precursors to AMPA/kainate receptor excitotoxicity may represent an important mechanism of white matter damage resulting from trauma or ischemia in the perinatal and adult central nervous system (CNS).
点击下载:
PDF
(727KB)
返 回