Several new classes of mesogenic heterocyclic liquid crystals with different terminal groups are presented. Their material properties are investigated and compared with those of 2,5-disubstituted pyridine derivatives. New compounds are found to exhibit broader temperature ranges and higher transition temperatures than their analogs. Data also reported on our structural investigations (X-ray scattering) which revealed the correlation with physico-chemical properties of new 2,6-disubstituted pyridine derivatives.