Cholecystokinin‐B receptor antagonists attenuate morphine dependence and withdrawal in rats
作者:
Lin Lu,
Mingsheng Huang,
Zhiyuan Liu,
and Ma,
期刊:
NeuroReport
(OVID Available online 2000)
卷期:
Volume 11,
issue 4
页码: 829-832
ISSN:0959-4965
年代: 2000
出版商: OVID
关键词: Agonist;Antagonist;Cholecystokinin;Extinction;Morphine dependence;Withdrawal
数据来源: OVID
摘要:
The possible effect of a cholecystokinin-8 agonist (caerulein) and antagonists (MK-329 and L365,260) on the development of morphine dependence and withdrawal were investigated in rats. Caerulein treatment (0.01 and 0.1 mg/kg) increased the incidence of naloxone-induced withdrawal syndromes and delayed the extinction of morphine-conditioned place preference in morphine-dependent animals. The signs of the morphine withdrawal syndromes and the formation of morphine-conditioned place preference were suppressed by pretreatment with L365,260 (0.1 and 1 mg/kg) and not affected by pretreatment with MK-329 (0.1 and 1 mg/kg). The present study demonstrated CCK, acting on CCK-B receptors, participates in the development of the opiate dependence. These findings suggest that CCK-B receptor antagonists might be of some value in the treatment and prevention the relapse of opiate addicts.
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