Can Tobramycin Inhalation Be Improved With a Jet Nebulizer?
作者:
Paul Le Brun,
Alexander Vinks,
Daan Touw,
Nicole Hekelaar,
Gregor Mannes,
Roland Brimicombe,
Erik Frijlink,
Harry Heijerman,
期刊:
Therapeutic Drug Monitoring
(OVID Available online 1999)
卷期:
Volume 21,
issue 6
页码: 618-618
ISSN:0163-4356
年代: 1999
出版商: OVID
关键词: Tobramycin;Inhalation;Pharmacokinetics;Jet nebulizer
数据来源: OVID
摘要:
SummaryData on the pharmacokinetics of antibiotics after inhalation are limited. The aim of this pilot study was to assess the pharmacokinetics of tobramycin under optimalized and standardized aerosol circumstances and, furthermore, to be able to consider possible treatment of exacerbations with inhalation therapy. Six patients were studied after inhalation of 600 mg tobramycin. A jet nebulizer loaded with a 10% solution of tobramycin in water was used. The percentage of the dose that was systemically absorbed ranged from 1.0% to 16.6%. The maximum serum levels of tobramycin ranged from 0.77 mg/L to 3.63 mg/L (mean 1.70 ± 1.01). The pharmacokinetic data were best described by a two-compartment model. Compared to intravenous administration, the long terminal half-life (mean 9.47 h ± 3.28 h) could be explained by the slow absorption of tobramycin from the site of administration (flip-flop model). Despite standardized aerosol conditions, considerable interpatient variability was observed. However, the relatively low serum levels allow a further increase of the dose.
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