Ceftazidime is a β -lactam antibiotic highly effective againstPseudomonas aeruginosainfection. Using a rabbit model of Pseudomonas keratitis, 103bacteria (in 20 µ l) were injected unilaterally into the corneal stroma of albino rabbits. Twenty-six hours after inoculation, topical Ceftazidime (50 mg/ml) drops were administered for 48 h, following which the corneal tissue was cultured. Eighteen of 20 corneal cultures (90%) from rabbits treated with Ceftazidime drops were negative. In comparison, all untreated control group cultures showed florid bacterial growth. These results suggest that topical Ceftazidime may be a useful agent in the treatment of P.aeruginosakeratitis.