Computed tomography (CT) is the modality of choice for evaluation of pancreatic disease. At present, dynamic and spiral CT are the optimal techniques for diagnosis and staging of patients with suspected pancreatic carcinoma. Images obtained with spiral CT showed superior vascular opacification compared with those obtained with dynamic CT. CT is more accurate in demonstrating tumor involvement of major peripancreatic vessels. CT staging criteria of unresectability are reliable. Indication for angiography is the preoperative assessment of patients who have resectable tumors with CT or the evaluation of equivocal CT/ERCP findings.