Detection of Glycosylated Protein in Renal Tissues and Dermal Vascular Vessels in the Microalbuminuric Stage of Diabetic Nephropathy Using the Nitro Blue Tetrazolium Reaction
作者:
Yasuhiko Tomino,
Akemi Saitoh,
Takao Kuramoto,
Hiroyuki Ohmuro,
Honggang Wang,
Isao Shirato,
Hikaru Koide,
Toshihiko Iijima,
Hisaki Rinno,
Akio Taneda,
期刊:
Nephron
(Karger Available online 1994)
卷期:
Volume 68,
issue 2
页码: 207-211
ISSN:1660-8151
年代: 1994
DOI:10.1159/000188258
出版商: S. Karger AG
关键词: Glycosylation;Vessels;NBT reaction;NIDDM
数据来源: Karger
摘要:
Detection of glycosylated protein in renal and dermal tissues was performed in patients in the microalbuminuric stage of diabetic nephropathy using the nitro blue tetrazolium (NBT) reaction. The intensity of NBT staining in glomeruli and dermal vascular vessels was marked in the microalbuminuric stage as well as in the overtly proteinuric stage. The NBT staining in the renal and dermal vascular walls in both stages was significantly stronger than in the samples of control autopsy patients. It appeared that nonenzymatic glycosylation in various tissues, i.e. kidneys and dermal vascular vessels, had already progressed in the microalbuminuric stage in patients with diabetic nephropathy.
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