A Genetic Study of Schizophrenia Pedigrees
作者:
R.C. Elston,
K.K. Namboodiri,
M.A. Spence,
J.D Rainer,
期刊:
Neuropsychobiology
(Karger Available online 1978)
卷期:
Volume 4,
issue 4
页码: 193-206
ISSN:0302-282X
年代: 1978
DOI:10.1159/000117633
出版商: S. Karger AG
关键词: Schizophrenia;Pedigree analysis;Monogenic models
数据来源: Karger
摘要:
One-locus models have been fitted to two sets of two-generational families, studied by Kallmann because each contained a schizophrenic twin proband; in one set each twin proband was in the nuclear group, in the other in the peripheral group. Allowing for a lognormal age of onset distribution and a dependence of ascertainment probability on age of onset, the following hypotheses were tested and rejected: ascertainment probability is a noncurvilinear function of age of onset on a log-log scale; the transmission of schizophrenia is via one Mendelian locus, and the transmission of schizophrenia is independent of parental type. The last hypothesis is more likely than one-locus Mendelian inheritance, but it too must be rejected.
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