Pharmakokinetik und klinische Wirksamkeit rektal verabreichter Theophylline
作者:
P. Bracher,
O. Brändli,
期刊:
Respiration
(Karger Available online 1982)
卷期:
Volume 43,
issue 6
页码: 458-466
ISSN:0025-7931
年代: 1982
DOI:10.1159/000194518
出版商: S. Karger AG
关键词: Theophylline;Diprophylline;Proxyphylline;Serum levels;Pulmonary function;Chronic obstructive lung disease;therapy
数据来源: Karger
摘要:
The bronchodilatory effect of Neo-Biphyllin Mikroklysma® (400 mg Theophylline [T], 600 mg Diprophylline [D], 600 mg Proxyphylline [P], corresponding to 5.2 mg/kg bodyweight of T, and 7.8 mg/kg of D and P, respectively) was studied on 5 consecutive days with one daily rectal application in a double-blind crossover design in 8 patients with chronic obstructive lung disease. Serum levels following rectal application are lower than after oral administration. On the 5th day they are only slightly higher than on the 1st day. The mean serum levels (μg/ml) achieved after 2 h are 6.1 for T, 1.0 for D and 7.7 for P, after 8 h 3.5 for T, 0.9 for D and 4.8 for P. The pulmonary function parameters (FEV1, VC, RV, TLC and Raw) show an improvement, however, in comparison with placebo the results are statistically not significant. A correlation between the serum levels and the functional improvement cannot be established, even after taking into consideration the equipotency on a weight-for-weight basis according to the in vitro effect of the three compounds on the isolated guinea pig trachea [Boardman, 1980]. No side effects or local intolerance were reported. The use of the combination enema is particularly suitable for children or self-application by adults. Yet according to our findings larger doses or more frequent applications are require
点击下载:
PDF
(1058KB)
返 回