Mechanism of Histamine Actions in Human Coronary Arteries
作者:
Noboru Toda,
期刊:
Circulation Research
(OVID Available online 1987)
卷期:
Volume 61,
issue 2
页码: 280-286
ISSN:0009-7330
年代: 1987
出版商: OVID
关键词: human coronary artery;histamine;endothelium-dependent relaxation;histamine H1and H2receptors
数据来源: OVID
摘要:
Helical strips of human coronary arteries contracted in response to histamine concentration dependently, they relaxed with low concentrations and contracted with high concentrations. Treatment with cimetidine potentiated contraction in the strips with intact and damaged endothelium to a similar extent and attenuated relaxation. Removal of endothelium abolished relaxation and potentiated contraction in the cimetidine-treated strips. Methylene blue increased the contractile response to histamine in the strips with endothelium but did not alter the response in the damaged-endothelium strips. Histamine-induced relaxations in the intact strips were suppressed or abolished by treatment with ETYA, AA861, a lipoxygenase inhibitor, and by chlorpheniramine but were unaffected by indomethacin. Chlorpheniramine also abolished amine-induced contraction. It may be concluded that histamine-induced contraction in human coronary arteries is mediated by H1receptors in smooth muscle, and relaxation is mediated by H2receptors in smooth muscle and H1receptors in endothelium. Also, stimulation of the endothelial H1receptor liberates vasodilator substance and possibly activates smooth muscle guanylate cyclase to accumulate cellular cyclic guanosine monophosphate.
点击下载:
PDF
(394KB)
返 回