首页   按字顺浏览 期刊浏览 卷期浏览 1H NMR Studies of Drugs with Achiral and Chiral Lanthanide Shift Reagents. CGP29953: An...
1H NMR Studies of Drugs with Achiral and Chiral Lanthanide Shift Reagents. CGP29953: Analog of the Aromatase Inhibitor, Aminoglutethimide

 

作者: Robert Rothchild,   Navroz Shariff,  

 

期刊: Spectroscopy Letters  (Taylor Available online 1998)
卷期: Volume 31, issue 7  

页码: 1335-1351

 

ISSN:0038-7010

 

年代: 1998

 

DOI:10.1080/00387019808001643

 

出版商: Taylor & Francis Group

 

关键词: Anti-cancer agent;Stereoisomers;Enantiomers;Eu(FOD)3;Eu(HFC)3;1-(4-Aminophenyl)-3-n-propyl-3-azabicyclo[3.1.0]hexane-2, 4-dione;One- and two-dimensional1H NMR

 

数据来源: Taylor

 

摘要:

1-(4-Aminophenyl)-3-n-propyl-3-azabicyclo[3.1.0]hexane-2, 4-dione, compound1(CGP29953), is an analog of the aromatase inhibitor aminoglutethimide (AG); AG has applications in cancer treatment. We have studied the1H NMR spectra of racemic compound1(in CDC13, ambient temperatures, 300-MHz) with the added achiral LSR, tris(6, 6, 7, 7, 8, 8, 8-heptafluoro-2, 2-dimethyl-3, 5-octanedionato) europium (III), compound2, and the chiral LSR, tris[3-(heptafluoropropylhydroxymethylene)-(+) - camphorato]europium (III), compound3. Use of compound3produced substantial enantiomeric shift differences for several nuclei of compound1.1H-1H COSY spectra were used to determine the relative sense of magnetic nonequivalence for selected nuclei of compound1with added compound3. Relative lanthanide induced shift (LIS) magnitudes for compound1. with added LSR are discussed.

 

点击下载:  PDF (582KB)



返 回