Treatment of Tourette's Syndrome with Calcium Antagonists
作者:
F. Micheli,
M. Gatto,
E. Lekhuniec,
C. Mangone,
M. Pardal,
R. Pikielny,
I. Parera,
期刊:
Clinical Neuropharmacology
(OVID Available online 1990)
卷期:
Volume 13,
issue 1
页码: 77-83
ISSN:0362-5664
年代: 1990
出版商: OVID
关键词: Tourette's syndrome;Nifedipine;Flunarizine
数据来源: OVID
摘要:
Six males and one female with chronic tic disorders, whose ages ranged from 12 to 31 years, were evaluated before treatment, after 1 month on placebo, after a single 10 mg nifedipine dose (three patients), and monthly while on flunarizine 10–15 mg (mean dose of 13 mg). None of the patients receiving nifedipine improved, but treatment with flunarizine significantly decreased both motor and phonic tic severity and frequency in all but one patient. Side effects included mild transient headaches in one patient, depression in one, and bradykinesia in two. Although a double-blind study is essential to validate our findings, results suggest that flunarizine is a useful drug in the treatment of Gilles de la Tourette syndrome.
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