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I‐125 and I‐123 labelled iodobenzyl bromide, a useful alkylating agent for radiolabelling biologically important molecules

 

作者: Alan A. Wilson,   Robert F. Dannals,   Hayden T. Ravert,   H. Donald Burns,   Henry N. Wagner,  

 

期刊: Journal of Labelled Compounds and Radiopharmaceuticals  （WILEY Available online 1986）
卷期: Volume 23, issue 1  

页码: 83-93

 

ISSN:0362-4803

 

年代: 1986

 

DOI:10.1002/jlcr.2580230111

 

出版商: John Wiley&Sons, Ltd.

 

关键词: Radioiodination;4‐iodobenzyl bromide;4‐trimethylsilylbenzyl bromide;I‐125;I‐123;lipophilic cations

 

数据来源: WILEY

 

摘要:

AbstractThe radioiodination of 4‐trimethylsilylbenzyl bromide in acetic acid with no carrier added I‐125 and I‐123 iodide ion and N‐chlorosuccinimide (NCS) is a rapid, high yielding process which produces high specific activity 4‐[I‐125 or I‐123]iodobenzyl bromide. This radiolabelled alkylating agent has been efficiently reacted with N,N‐dimethylaniline and triphenylphosphine to generate radiolabelled quaternary ammonium and phosphonium salts, and should be useful for labelling other biologically important molecules which possess suitable nucleophilic fu

 

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