Explants of highly metastatic human renal cell carcinoma SN12Cpm6 cells In athymic mice were treated with sodium D-glucaro-δ-lactam; (sodium 5-amino-5-deoxy-D-glucosaccharic acid-δ-lactam; ND-2001). ND-2001 (50µg/ml) caused 78% inhibition of lung metastasis of SN12Cpm6 cells (two of five animals remaining metastasis free). TheIn vitrotumor cell invasion assay showed that ND-2001 (100µg/ml) suppressed the invasive activity of SN12Cpm6 cells to Matrigel matrix at an inhibition rate of 72%. These results suggest that ND-2001 may be a new anti-metastatic drug against human cancer cells.