Wheat Germ and Peanut Agglutinin Binding to Normal, Dysplastic and Neoplastic Cervical Epithelium
作者:
Vladimir Bychkov,
Patrick D. Toto,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1986)
卷期:
Volume 21,
issue 3
页码: 158-163
ISSN:0378-7346
年代: 1986
DOI:10.1159/000298947
出版商: S. Karger AG
关键词: Wheat germ agglutinin;Peanut agglutinin;Lectins;Cervix;Neoplasia;Dysplasia;Atypia
数据来源: Karger
摘要:
Binding of wheat germ agglutinin (WGA) and peanut agglutinin (PNA) was studied cytochemically in 43 cervical specimens covering a range of lesions from moderate atypia to invasive carcinoma. Normal squamous epithelium showed weak binding of WGA and negative reaction with PNA. Atypical squamous epithelium was characterized by moderate binding of WGA and PNA, while malignant lesions demonstrated strong affinity to both lectins. In adenocarcinoma in situ, WGA and PNA binding was reduced by comparison with normal glandular epithelium, that was strongly positive.
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