Abstract5‐HT uptake inhibitors have a definite place in the treatment of mood disorders, although their primary target is uncertain. Mood‐, anxiety‐, and aggression‐regulation are the most likely candidates. 5‐HT uptake inhibitors are also effective in Panic Disorder and OCD, where the primary target in PD is probably anxiety and in OCD either anxiety or aggression. It is recommended that 5‐HT uptake blockers should be studied in aggression disorders.Furthermore, it is concluded that the range of indications of selective 5‐HT uptake blockers can better be described dimensionally than nosologically, leading to a new era of clinical psychopharmacology, described as functional psych