Modification of the phenotypic expression of murine dystrophy: A morphological study
作者:
Dianna L. Bourke,
Marcia Ontell,
期刊:
The Anatomical Record
(WILEY Available online 1986)
卷期:
Volume 214,
issue 1
页码: 17-24
ISSN:0003-276X
年代: 1986
DOI:10.1002/ar.1092140104
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractThe extensor digitorum longus muscles of 4–6‐week‐old normal mice (129 ReJ) and dystrophic mice (129 ReJ dy/dy) were orthotopically transplanted. Grafted muscles were examined 1, 3, 7, 14, 20, 50, and 100 days post‐transplantation. The myofibers of both types of grafts underwent a similar time course of necrosis and regeneration. Other than during the initial necrotic response, no evidence of necrotic myofibers was found in either type of grafted muscle. At 100 days post‐transplantation, the grafted normal and dystrophic muscles were essentially similar, except that the dystrophic graft was of smaller size. Based on a comparison of the number of myofibers found at the 100‐day grafts' widest girths [631 ± 59 SEM, for normal grafts (Bourke and Ontell, 1984); 631 ± 74 SEM, for dystrophic grafts], it is suggested that the regenerative capability of traumatized 4–6‐week‐old dystrophic muscle is similar to that of traumatized normal muscle. At 100 days post‐transplantation, the grafted dystrophic muscle appeared “healthier” than untraumatized muscle from age‐matched dystrophic mice, having less variation in myofiber diameter, better fascicular organization, and less connective tissue. The transplantation system demonstrates the possibility of modifying the expression of genetic programming of myopathic disorders using
点击下载:
PDF
(1156KB)
返 回