Depending on the Time of Administration, Dexamethasone Potentiates or Blocks Growth Hormone-Releasing Hormone-Induced Growth Hormone Release in Man
作者:
Felipe F. Casanueva,
Bartolome Burguera,
M. Ausencia Tome,
Luis Lima,
Jesus A.F. Tresguerres,
Jesus Devesa,
Carlos Dieguez,
期刊:
Neuroendocrinology
(Karger Available online 1988)
卷期:
Volume 47,
issue 1
页码: 46-49
ISSN:0028-3835
年代: 1988
DOI:10.1159/000124889
出版商: S. Karger AG
关键词: Growth hormone;Growth hormone-releasing hormone;Growth hormone release corticoids;Dexamethasone
数据来源: Karger
摘要:
In humans, corticoids suppress growth hormone (GH) secretion elicited by a variety of stimuli, while in vitro they potentiate GH release. To further study this problem, the effect of two doses of dexamethasone on GH secretion elicited by GH-releasing hormone (GHRH) in 6 normal volunteers was studied. Each subject underwent three tests, on 3 separate days with GHRH 1–29 (1 µg/kg i.v. at 12.00 h). On the control day, only GHRH was given, on the second day dexamethasone 4 mg i.v. was administered at 09.00 h (3 h before GHRH) and on the third day dexamethasone 8 mg p.o. was given 12 h before GHRH (at 00.00 h). The GHRH-induced GH peak was 9.9 ± 2.0 ng/ml, while 4 mg dexamethasone significantly (p < 0.05) potentiated GH secretion elicited by GHRH (29.2 + 5.7 ng/ml). When dexamethasone 8 mg was given 12 h before, GHRH-induced GH secretion was completely blocked (3.0 + 1.1 ng/ml) (p < 0.05). These results indicate that corticoids have two different actions: an acute potentiating activity on GHRH, and a delayed blocking action on GHRH-induced GH secret
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