NPY Y1receptors in the dorsal periaqueductal gray matter regulate anxiety in the social interaction test
作者:
Ants Kask,
Lembit Rägo,
Jaanus Harro,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 12
页码: 2713-2716
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: 1229U91;Anxiety;Dorsal periaqueductal gray;BIBP3226;Neuropeptide Y;Y1receptor;NPY Y1receptor antagonist;Social behaviour
数据来源: OVID
摘要:
WE have reported previously that the NPY Y1receptor antagonist BIBP3226 applied into the dorsal periaqueductal gray matter (DPAG) has an anxiogenic-like effect in the elevated plus-maze test in rats. In the present study the effects of neuropeptide Y (NPY) Y1receptor antagonists BIBP3226 (500 pmol) and 1229U91 (formerly also GR231118, GW1229 and EXBP68, 100 and 500 pmol) administered into the DPAG were investigated in the social interaction test in rats. BIBP3226 and 1229U91 (both 500 pmol) significantly decreased the time spent in active social interaction. These results provide additional evidence that NPY-ergic neurotransmission in the DPAG may be involved in the modulation of anxiety-related behaviour and suggest that endogenous NPY, released under stressful conditions in the DPAG, relieves anxiety via the NPY Y1receptors. This is the first report demonstrating the effect of NPY receptor active agent on social behaviour.
点击下载:
PDF
(328KB)
返 回