Effect of dairy products on initiation of precursor lesions of colon cancer in rats
作者:
AbdelaliHasnaà,
CassandPierrette,
SoussotteValérie,
DaubezeMichéle,
BouleyChristine,
NarbonneJeanF.,
期刊:
Nutrition and Cancer
(Taylor Available online 1995)
卷期:
Volume 24,
issue 2
页码: 121-132
ISSN:0163-5581
年代: 1995
DOI:10.1080/01635589509514400
出版商: Taylor&Francis Group
数据来源: Taylor
摘要:
AbstractThis study reports the modulating effect of some dairy products on initiation of putative preneoplasic lesions in rat colon (aberrant crypts) by 1,2‐dimethylhydrazine dihydrochloride. Uninoculated skim milk, skim milk fermented with Bifidobacterium sp Bio (Danone strain 173010), and a suspension of the same lactic acid bacteria were incorporated in the animals’diet. The tested diets significantly reduced the incidence of aberrant crypts compared with the control diet by 51%, 49%, and 61%, respectively.The effects of the diets on cecal pH, hepatic UDP‐glucuronyltransferase activity, and cecal microflora enzymeβ‐glucuronidase were also studied. There was no significant difference in cecal pH between rats fed experimental diets and control rat. The diet supplemented with the Bifidobacterium strain suspension significantly decreased only the cecalβ‐glucuronidase activity. Both enzyme activities were reduced in rats fed fermented skim milk‐or uninoculated skim milk‐supplemented diets compared with control animals.
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