Monocyte deactivation in septic shock
作者:
Didier Heumann,
Michel Glauser,
Thierry Calandra,
期刊:
Current Opinion in Infectious Diseases
(OVID Available online 1998)
卷期:
Volume 11,
issue 3
页码: 279-284
ISSN:0951-7375
年代: 1998
出版商: OVID
数据来源: OVID
摘要:
Septic shock is a complicated syndrome in which pro-inflammatory and anti-inflammatory processes are dynamically interconnected and regulated. Central to these processes is the monocyte, which produces large quantities of pro-inflammatory cytokines in the presence of bacterial products. During the course of sepsis, the production of compensatory anti-inflammatory mechanisms may deactivate monocytes and lead to a stated paralysis. This situation is in fact similar but not identical to that known as tolerance, in which normal monocytes prechallenged with lipopolysaccharide do not respond to a second challenge of lipopolysaccharide. Here, we review some of the cellular mechanisms that may lead to monocyte deactivation and discuss the clinical implications they may have.
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