The caregiving literature has focused on European-American caregivers who are providing care to spouses or parents with Alzheimer's disease. The article reports ethnographic research exploring aspects of caregiving by rural African-American mothers for adult children with human immunodeficiency virus (HIV) disease. Eight African-American mothers were interviewed to elicit cultural domains of caregiving. Two major domains were a personal relationship with God and God's will. Taken together, these domains framed the context in which African-American mothers understood HIV disease, provided care, and resolved the death of their adult child.