The Effect of Ketanserin, a Specific Serotonin Antagonist, on Burn Shock Hemodynamic Parameters in a Porcine Burn Model
作者:
C. HOLLIMAN,
THOMAS MEULEMAN,
KENNETH LARSEN,
J. PORT,
TED STANLEY,
NATHAN PACE,
GLENN WARDEN,
期刊:
The Journal of Trauma: Injury, Infection, and Critical Care
(OVID Available online 1983)
卷期:
Volume 23,
issue 10
页码: 867-871
ISSN:0022-5282
年代: 1983
出版商: OVID
数据来源: OVID
摘要:
A number of vasoactive substances, including serotonin, have been implicated in the pathophysiology of burn shock. Ketanserin, a specific serotonin antagonist, was investigated in a porcine burn shock model. Fifteen swine were given a mean 44% total body surface area full-thickness scald burn and received fluid resuscitation with Ringer's lactate for 24 hours postburn. The swine were divided into three groups: Group I (control group) received no ketanserin; Group II received ketanserin as a single intramuscular dose preburn and continuously via intravenous drip postburn; and Group III received ketanserin continuously via intravenous drip postburn only. The ketanserin-treated groups demonstrated improved cardiac index, decreased pulmonary artery pressures, and smaller arteriovenous oxygen content differences compared to the control group in the early postburn period. Ketanserin should be investigated further as a possible adjunctive therapeutic agent during burn shock resuscitation.
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