首页   按字顺浏览 期刊浏览 卷期浏览 Analysis of the serum paraoxonase/arylesterase polymorphism in a Turkish population
Analysis of the serum paraoxonase/arylesterase polymorphism in a Turkish population

 

作者: A Karakaya,   S Suzen,   S Sardas,   A E Karakaya,   N Vural,  

 

期刊: Pharmacogenetics  (OVID Available online 1991)
卷期: Volume 1, issue 1  

页码: 58-61

 

ISSN:0960-314X

 

年代: 1991

 

出版商: OVID

 

数据来源: OVID

 

摘要:

Human serum paraoxonase is a polymorphic enzyme that is capable of catalyzing the hydrolysis of paraoxon and other organophosphates, some carbamates and certain aromatic carboxylic acid esters. This enzyme is specified by two allelic genes at one autosomal locus (isozymes ‘A’ and ‘B’). The purpose of this study was to examine the paraoxonase activity of 105 Turkish subjects. Paraoxonase activities ranged from 39.6 to 278.2 nmol p-nitrophenol formed per ml of serum per min. Paraoxonase phenotypes could be clearly identified by salt and paraoxonase:arylesterase activity ratio characteristics. The gene frequencies were 0.632 for the low activity allele (A) and 0.368 for the high activity allele (B).

 

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