A non‐parametric graphical representation of the relationship between survival and the occurrence of an event: Application to responder versus non‐responder bias
作者:
Richard Simon,
Robert W. Makuch,
期刊:
Statistics in Medicine
(WILEY Available online 1984)
卷期:
Volume 3,
issue 1
页码: 35-44
ISSN:0277-6715
年代: 1984
DOI:10.1002/sim.4780030106
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: Clinical trial;Non‐parametric survival function estimator;Time‐dependent covariate Transient state analysis
数据来源: WILEY
摘要:
AbstractReports of cancer clinical trials often attempt to evaluate whether tumour response is associated with prolonged survival. Proper analysis requires accounting for the time‐dependent nature of response status. We review a valid and relatively simple method of significance testing for this problem, and develop a corresponding non‐parametric method for displaying the association between survival and occurrence of response. The new method applies to many other clinical problems involving representation and the association between survival and the occurrence of an event. We illustrate the method with data from two clinical tri
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