O-4-O-6 Acetyl migrations in partially O-acetylated 2- and 3-acylamidodeoxyhexopyranosides, including derivatives of kanamycin A, were found to be particularly suited to allow the regiospecific accessibility of their respectiveC-4OHgroups. PartiallyO-acetylatedd-glucopyranosides, compared to the substrates above, showed slightly different aptitudes of migration. However, allO-4-O-6 migrations investigated proved to be irreversible under the conditions applied.