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Isolation and Structure Characterization of Two Novel Bioactive Sulphated Polyhydroxysteroids from the Antarctic OphiuroidOphioderma longicaudum

 

作者: MariaValeria D'auria,   LuigiGomez Paloma,   Luigi Minale,   Raffaele Riccio,   Angela Zampella,   Mariella Morbidoni,  

 

期刊: Natural Product Letters  （Taylor Available online 1993）
卷期: Volume 3, issue 3  

页码: 197-201

 

ISSN:1057-5634

 

年代: 1993

 

DOI:10.1080/10575639308043863

 

出版商: Taylor & Francis Group

 

关键词: bioactive sulphated polyhydroxysteroids;ophiuroids

 

数据来源: Taylor

 

摘要:

Two novel sulphated polyhydroxysteroids,1, possessing potent cytotoxic activity, and2, which proved to be cytoprotective against HIV-1, have been isolated from the Antarctic ophiuroidOphiosparte gigas, together with the known tetrol disulphated3. The structures of1and2have been determined to be cholest-5-ene-2α,3α,4β, 21-tetraol 3, 21-disulphate and cholest-5-ene-2β,3α, 21-triol 2, 21-disulphate, respectively.

 

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