Prolactin as a luteotrophin
作者:
Bruce D. Murphy,
Kadaba Rajkumar,
期刊:
Canadian Journal of Physiology and Pharmacology
(NRC Available online 1985)
卷期:
Volume 63,
issue 3
页码: 257-264
ISSN:0008-4212
年代: 1985
DOI:10.1139/y85-047
出版商: NRC Research Press
数据来源: NRC
摘要:
This review summarizes evidence suggesting a direct luteotrophic role for the hypophyseal hormone prolactin (PRL). This direct role consists of the capability to stimulate progesterone synthesis in vitro, the capability to maintain the membrane fluidity and receptors for luteinizing hormone and the capability to import substrate for progesterone synthesis. The time required for PRL-induced luteotrophic events is in the order of hours and sometimes days, and it appears that the effects are not associated with acute intracellular changes. The relatively slow responses and the stimulation of specific protein synthesis by PRL in target tissues other than the ovary suggest that PRL may function primarily through activation of the genome. PRL may induce the synthesis of specific luteal proteins, including enzymes for the regulation of intracellular substrate pools, membrane receptors for LH, or receptor proteins for lipoproteins, a major extracellular source of substrate.
点击下载:
PDF
(1606KB)
返 回