Carbohydrate Metabolism in Patients with Nephrotic Syndrome and Normal Renal Function
作者:
C. Loschiavo,
A. Lupo,
E. Valvo,
N. Tessitore,
S. Ferrari,
A. Corgnati,
G. Maschio,
期刊:
Nephron
(Karger Available online 1983)
卷期:
Volume 33,
issue 4
页码: 257-261
ISSN:1660-8151
年代: 1983
DOI:10.1159/000182964
出版商: S. Karger AG
关键词: Nephrotic syndrome;Blood glucose;Insulin;Growth hormone;Cortisol
数据来源: Karger
摘要:
The effects of a standard oral glucose tolerance test (OGTT) on the serum concentrations of glucose, insulin, growth hormone (GH) and cortisol were evaluated in 38 adult patients with primary nephrotic syndrome and with normal renal function, and in 10 normal subjects. 14 patients had a diabetic-like response and 24 were not different from controls. In both groups of patients an increase in insulin pool secretion, probably due to elevated serum GH levels, was observed. The increased GH values were not related to serum albumin nor to urinary protein losses. No significant difference in serum cortisol values was observed in patients with nephrotic syndrome as compared to controls. There was no strict correlation between the various histologic lesions and the metabolic abnormalities. However, patients with a diabetic-like response to OGTT had a higher frequency of membranous glomerulopathy or focal glomerular sclerosis.
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