Long‐term effects of colchicine on dentinogenesis in rat incisors
作者:
TEREZINHA DE OLIVEIRA NOGUEIRA,
TORBJØRN STENE,
HANNA STRØMME KOPPANG,
期刊:
European Journal of Oral Sciences
(WILEY Available online 1980)
卷期:
Volume 88,
issue 1
页码: 15-21
ISSN:0909-8836
年代: 1980
DOI:10.1111/j.1600-0722.1980.tb00714.x
出版商: Blackwell Publishing Ltd
关键词: colchicine;dentinogenesis;rat incisor
数据来源: WILEY
摘要:
Abstract –Colchicine in doses of 0.5, 1.0 and 1.5 mg/kg was administered to 15 rats divided in three experimental groups. Histomorphologic investigation of the maxillary incisors after 2 weeks revealed; 1) alterations in the odontoblasts mainly related to size, shape, polarity and staining properties, and 2) presence of irregular dentin separated from normal dentin by one or two incremental lines. The dentinal irregularities were dose‐dependent and consisted of twisting of the dentinal tubules, globular formations and cellular inclusions in addition to niche‐like de
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