Effect of 7‐nitroindazole on body temperature and methamphetamine‐induced dopamine toxicity
作者:
Brian Callahan,
George Ricaurte,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 12
页码: 2691-2695
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Dopamine;Methamphetamine;Neurotoxicity;Nitric oxide;7-Nitroindazole;Temperature
数据来源: OVID
摘要:
THE present study was undertaken to examine the role of temperature on the ability of 7-nitroindazole (7-NI) to prevent methamphetamine-induced dopamine (DA) neurotoxicity. Male Swiss-Webster mice received methamphetamine alone or in combination with 7-NI at either room temperature (20 ± 1°C) or at 28 ± 1°C. At 20°C, 7-NI produced hypothermic effects and afforded total protection against methamphetamine-induced DA depletions in the striatum. At 28 ± 1°C, 7-NI produced minimal effects on body temperature and failed to prevent methamphetamine-induced DA reductions. These findings indicate that the neuroprotection afforded by 7-NI is likely related to its ability to produce hypothermia because agents that produce hypothermia and/or prevent hyperthermia are known to attenuate methamphetamine-induced neurotoxicity.
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