Contractile Responses to Ouabain and Potassium-Free Solution in Vascular Tissue from Renal Hypertensive Rats
作者:
J Hurley Myers,
Fred Lamb,
R Clinton Webb,
期刊:
Journal of Hypertension
(OVID Available online 1987)
卷期:
Volume 5,
issue 2
页码: 161-171
ISSN:0263-6352
年代: 1987
出版商: OVID
关键词: Electrogenic sodium pump;vascular smooth muscle;arteries;veins
数据来源: OVID
摘要:
This study characterizes contractions to ouabain and potassium-free solution in isolated vascular segments from two-kidney, one clip (2-K, 1C) hypertensive rats. Aorta, mesenteric artery, and vena cava from hypertensive rats were more sensitive (lower threshold) to ouabain than those from normotensive rats. Contractions of hypertensive vascular segments to potassium-free solution and to ouabain (10-3mol/l) were faster than those in normotensive vessels. Monensin potentiated contractions to ouabain and increased the rate of force development to potassium-free solution to a greater extent in normotensive aortae than in hypertensive aortae. Amiloride, low sodium solution, verapamil and calcium-free solution depressed contractions to ouabain and potassium-free solution in both hypertensive and normotensive aortae. These observations demonstrate augmented responsiveness to ouabain and potassium-free solution in hypertensive blood vessels. Interventions which influence transmembrane sodium and calcium movements altered contractions to ouabain and potassium-free solution. The results are consistent with the hypothesis that vascular cells of hypertensive rats have enhanced sodium pump activity.
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