Pharmacokinetics and bioavailability of ronidazole from a prolonged release tablet in the homing pigeon (Columba livid)
作者:
J. HERMAN,
H. VERMEERSCH,
J. P. REMON,
P. DE BACKER,
期刊:
Journal of Veterinary Pharmacology and Therapeutics
(WILEY Available online 1989)
卷期:
Volume 12,
issue 1
页码: 46-49
ISSN:0140-7783
年代: 1989
DOI:10.1111/j.1365-2885.1989.tb00640.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
The pharmacokinetics of ronidazole and the bioavailability of a prolonged release tablet were studied in the homing pigeon. After intravenous administration of 5 mg ronidazole, the drug plasma concentration profile fitted a one‐compartment open model. The mean half‐life of the drug was 11 h and the volume of distribution was 0.86 I/kg. Total body clearance was 0.056 I/h/kg. A sustained release matrix tablet exhibited prolonged drug releasein vitro.After oral administration of the matrix tablet to pigeons drug absorption was nearly complete. When given on an empty stomach, the tablet failed as a prolonged release system. Administration to previously fed pigeons resulted in an increase intpmAXand a decrease inCp
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