The Effect of Methylprednisolone on Hypoxic Pulmonary Vasoconstriction in the Newborn Late-Gestation Lamb
作者:
GAD ALPAN,
RONALD CLYMAN,
期刊:
Pediatric Research
(OVID Available online 1990)
卷期:
Volume 27,
issue 2
页码: 133-136
ISSN:0031-3998
年代: 1990
出版商: OVID
数据来源: OVID
摘要:
Methylprednisolone (30 mg/kg), which inhibits a number of mediators of hypoxic pulmonary vasoconstriction derived from arachidonic acid, has been found to alleviate hypoxic pulmonary vasoconstriction in adult humans and in the isolated rat lung preparation. We studied the effect of 30 mg/kg of methylprednisolone on the pulmonary vascular response to hypoxia in six late-gestation newborn lambs. During hypoxia, pulmonary vascular resistance nearly doubled compared with the baseline hyperoxic state. This was true both before and after administration of methylprednisolone. We conclude that methylprednisolone, when administered at the dosage used in previous studies of adult humans and animals, does not affect the response of the pulmonary vascular bed to hypoxia in newborn lambs.
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