Spectroscopic Study of the Interaction of Mitoxantrone with Copper(I), Copper(II), and Neocuproine
作者:
Raşat Apak,
Esme Tütem,
期刊:
Spectroscopy Letters
(Taylor Available online 1994)
卷期:
Volume 27,
issue 9
页码: 1255-1269
ISSN:0038-7010
年代: 1994
DOI:10.1080/00387019408006978
出版商: Taylor & Francis Group
关键词: Mitoxantrone;copper(I);copper(II);neocuproine;bis(2,9-dimethyl-1,10-phenanthroline) copper complexes;charge-transfer complexes;visible spectroscopy;antitumor activity
数据来源: Taylor
摘要:
Both reductive and oxidatlve mode of metabolism have been hypothesized for the antitumor agent mitoxantrone. This work aims to better understand the redox properties of mitoxantrone in the presence of the physiological redox couple, copper(I)/copper(II), by means of polarograpy and spectrophotometry. The first quasi-reversible one-electron reduction of mitoxantrone to the semiquinone and the second reduction to the hydroquinone have been shown to be considerably affected by copper. Visible spectra of mitoxantrone-copper mixtures in nitrogen and oxygen purged solutions taken in a one-week period exhibit varying degrees of complexation and oxido-reduction.
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