Hereditary Thrombotic Thrombocytopenic Purpura: Microangiopathic Hemolytic Anemia, Thrombocytopenia, and Renal Insufficiency Occurring in Consecutive Generations
作者:
Kent A. Kirchner,
Ray M. Smith,
Jon P. Gockerman,
Robert G. Luke,
期刊:
Nephron
(Karger Available online 1982)
卷期:
Volume 30,
issue 1
页码: 28-30
ISSN:1660-8151
年代: 1982
DOI:10.1159/000182427
出版商: S. Karger AG
关键词: Microangiopathic hemolytic anemia;Thrombotic thrombocytopenic purpura;Hemolytic uremic syndrome.
数据来源: Karger
摘要:
Microangiopathic hemolytic anemia, thrombocytopenia, and renal insufficiency occurred in a mother and daughter when each was in her third decade. The mother had prominent neurological findings, fever, and expired from renal insufficiency. Her daughter’s only major symptom was renal insufficiency. The similarity of the mother’s illness to thrombotic thrombocytopenic purpura and of the daughter’s to adult hemolytic uremic syndrome suggests that these diseases are variants of a single clinical disorder, while their occurrence in direct descendents strengthens the postulate that in selected instances a genetic predisposition to these disorders may be impo
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