AbstractIn continuing search of the structure‐activity relationship of heterocyclic chromones, 4‐quinolyl and 3‐quinolyl moieties were each introduced to the C‐2 position of chromones. A total of 12 quinolyl chromones were synthesized. 4‐Quinolinecarboxaldehyde was condensed with 2‐hydroxyacetophenones to provide the chalcones. These intermediates were then subjected to selenium dioxide dehydrogenation to yield the 6 new 4‐quinolyl chromones. 3‐Quinolinecarboxaldehyde was condensed with 2‐hydroxyacetophenones in the presence of dilute alkali to give aldol compounds of chalcones (dehydration products of aldols). Ring cyclization of the chalcones yielded the other 6 new 3